Short-term results of the pulmonary embolism treatment

Authors

  • A. S. Nikonenko
  • A. A. Nikonenko
  • S. A. Matvieiev

DOI:

https://doi.org/10.14739/2310-1210.2015.4.50307

Keywords:

Pulmonary Embolism, Thrombolytic Therapy, Pulmonary hypertension, Anticoagulants

Abstract

Aim. Acute pulmonary embolism (PE) is a common and often fatal disease with the level of mortality in the acute phase from 7 to 11%. In order to develop indications to thrombolytic therapy the short-term results of treatment with the use of combination therapy were studied. This treatment included: thrombolysis and /or anticoagulant therapy, with the usage of new oral anticoagulants and treatment of acute pulmonary hypertension. 231 patients with pulmonary embolism were examined.

Methods and results. Angiography, echocardiography, multidetector computed tomography of the chest were used to evaluate the results of treatment. Among those groups prevailed elderly and senile patients with concomitant chronic disorders of the cardiovascular and respiratory systems. This for certain significantly worsens pulmonary embolism. Therefore, thrombolysis was used in cases of  massive and submassive pulmonary embolism and as well as prostaglandin E1 drugs were used for the treatment of acute pulmonary hypertension and new oral anticoagulants. It was found that this treatment regimen resulted to a significant clinical improvement, restoration of adequate pulmonary blood flow and pulmonary hypertension rate decrease.

References

Fesmire, F. M., Brown, M. D., Espinosa, J. A., Shih, R. D., Silvers, S. M., Wolf, S. J., & Decker, W. W. (2011). Critical issues in the evaluation and management of adult patients presenting to the emergency department with suspected pulmonary embolism. Annals of Emergency Medicine, 57(6), 628–652. doi: 10.1016/j.annemergmed.2011.01.020.

Buppajarntham, S., Seetha Rammohan, H. R., Junpaparp, P., & Figueredo, V. M. (2014). Prognostic value of prolonged QTc interval patient with acute pulmonary embolism. Acta Cardiologica, 69(5), 550–555.

Marti, C., John, G., Konstantinides, S., Combescure, C., Sanchez, O., Lankeit, M., Meyer, G., & Perrier, A. (2015). Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis. European Heart Journal, 36(10), 605–614. doi:10.1093/eurheartj/ehu218.

Tubaro, M., Vranckx, P., Price, S., & Vrints, C. (Eds.). (2015). The ESC textbook of intensive and acute cardiovascular care. Second edition. European Society of Cardiology.

Konstantinides, S. V., Torbicki, A., Agnelli, G., Danchin, N., Fitzmaurice, D., Galiè, N., et al. (2014). 2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). European Heart Journal, 35, 3033–3073. doi: 10.1093/eurheartj/ehu283.

Nakamura, S., Takano, H., Kubota, Y., Asai, K., & Shimizu, W. (2014). Impact of the efficacy of thrombolytic therapy on the mortality of patients with acute submassive pulmonary embolism: a meta-analysis. Journal of Thrombosis and Haemostasis, 12(7), 1086–1095. doi: 10.1111/jth.12608.

Guyatt, G. H., Akl, E. A., Crowther, M., Gutterman, D. D., & Schunemann, H. J. (2012). Executive summary: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest, 141(2), 7S–47S. doi: 10.1378/chest.1412S3.

Daley, M. J., Murthy, M. S., & Peterson, E. J. (2015). Bleeding risk with systemic thrombolytic therapy for pulmonary embolism: scope of the problem. Therapeutic Advancesin Drug Safety, 6(2), 57–66. doi: 10.1177/2042098615572333.

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How to Cite

1.
Nikonenko AS, Nikonenko AA, Matvieiev SA. Short-term results of the pulmonary embolism treatment. Zaporozhye Medical Journal [Internet]. 2015Sep.16 [cited 2024Nov.5];17(4). Available from: http://zmj.zsmu.edu.ua/article/view/50307

Issue

No. 4 (2015): Zaporozhye medical journal

Section

Original research

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