Diagnostic usefulness of Galectin-3 in thyroid gland nodular lesions

Authors

  • D. I. Kebalo CRDC COMREC,
  • N. P. Miroshnykova CRDC COMREC,
  • K. N. Yurchenko CRDC COMREC,
  • S. M. Pashchenko State Institution Zaporizhzhia Medical Academy of Post-graduate education of MoH of Ukraine,
  • O. D. Zvantseva Zaporizhzhia Regional Clinical Oncology Hospital,
  • L. M. Fudashkina Zaporizhzhia Regional Clinical Oncology Hospital,

DOI:

https://doi.org/10.14739/2310-1210.2015.6.57017

Keywords:

Thyroid Neoplasms, Galectin-3, Immunohistrochemistry

Abstract

Aim. The objective of this study was to evaluate the diagnostic usefulness of Galectin-3 marker in the diagnosis of thyroid nodules.

Methods and results. results of immunocytochemical method for the expression of a tumor marker of galectin-3 in samples taken with the suction puncture biopsy of the thyroid gland in 230 patients were studied. It was established that immunocytochemical method of survey in material malignantion of thyroid tumors in 90–95% of cases observed  bright reaction to galectin-3 in foulliculy and papillary thyroid cancer. In benign tumors this reaction was weak or was absent.

Conclusion. This gives rise to the application of this method to identify malignant tumors of the thyroid gland or in the differential diagnostics of malignant and benign tumors of the thyroid gland.

References

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How to Cite

1.
Kebalo DI, Miroshnykova NP, Yurchenko KN, Pashchenko SM, Zvantseva OD, Fudashkina LM. Diagnostic usefulness of Galectin-3 in thyroid gland nodular lesions. Zaporozhye Medical Journal [Internet]. 2015Dec.29 [cited 2024Sep.27];17(6). Available from: http://zmj.zsmu.edu.ua/article/view/57017

Issue

No. 6 (2015): Zaporozhye medical journal

Section

Original research

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