Diagnostic usefulness of Galectin-3 in thyroid gland nodular lesions

Authors

  • D. I. Kebalo CRDC COMREC,
  • N. P. Miroshnykova CRDC COMREC,
  • K. N. Yurchenko CRDC COMREC,
  • S. M. Pashchenko State Institution Zaporizhzhia Medical Academy of Post-graduate education of MoH of Ukraine,
  • O. D. Zvantseva Zaporizhzhia Regional Clinical Oncology Hospital,
  • L. M. Fudashkina Zaporizhzhia Regional Clinical Oncology Hospital,

DOI:

https://doi.org/10.14739/2310-1210.2015.6.57017

Keywords:

Thyroid Neoplasms, Galectin-3, Immunohistrochemistry

Abstract

Aim. The objective of this study was to evaluate the diagnostic usefulness of Galectin-3 marker in the diagnosis of thyroid nodules.

Methods and results. results of immunocytochemical method for the expression of a tumor marker of galectin-3 in samples taken with the suction puncture biopsy of the thyroid gland in 230 patients were studied. It was established that immunocytochemical method of survey in material malignantion of thyroid tumors in 90–95% of cases observed  bright reaction to galectin-3 in foulliculy and papillary thyroid cancer. In benign tumors this reaction was weak or was absent.

Conclusion. This gives rise to the application of this method to identify malignant tumors of the thyroid gland or in the differential diagnostics of malignant and benign tumors of the thyroid gland.

References

Abrosimov, A. Yu., & Dvinskikh, N. Yu. (2009). Immunomorfologicheskie issledovaniya v ocenke potenciala zlokachestvennosti opukholej shchitovidnoj zhelezy [Immunomorphological studies of malignancy potential of thyroid cancer]. Voprosy oncologii, 6, 684–691. [in Russian].

Volchenko, N. N., & Savostikova, M. V. (2010). Atlas citologicheskoj i immunocitokhimicheskoj diagnostiki opukholej [Atlas cytological and immunocytochemical diagnosis of tumors]. Moscow. [in Russian].

Bondarenko, О. O., Shponka, Sh. S., & Hrytsenko, P. A. (2009). Vykorystannia onkomarkeriv v morfolohichnii diahnostytsi epitelialnykh pukhlyn shchytovydnoi zalozy [Using of oncomarkers in morphological diagnostics of epithelial tumors of thyroid gland]. Morfolohiia, 3(2), 12–16. [in Ukrainian].

Volchenko, N. N., Reshetov, I. V., Stavnova, Ye. N., Borisova, O. V., & Golubtsov, A. K. (2008). Immunocitokhimicheskoe issledovanie v citologicheskoj diagnostike papillyarnogo raka i dobrokachestvennykh obrazovanij shchitovidnoj zhelezy [Immunocytochemical study of papilliferous carcinoma and benign neoplasms of the thyroid ]. Rossijskij onkologicheskij zhurnal, 6, 17–21. [in Russian].

Gerval'd, V. J., Klimachev, V. V., Avdaljan, A. M., Ivanov, A. A., Bobrov, I. P., Lepilov, A. V., et al. (2014). Rak shchitovidnoj zhelezy i metody ego immunogistokhimicheskoj diagnostiki [The thyroid cancer and its immunohistochemical diagnosis]. Fundamental′nye issledovaniya, 10, 1911–1917. [in Russian].

Kogan, E. A., Petunina, N. A., Chernyshova, T. V., & Lukyanchenko, D. V. (2011). Opredelenie e′kspressii galektina-3 v tkani follikulyarnykh opukholej shchitovidnoj zhelezy [Determination of galectin-3 expression in the tissue of follicular thyroid tumors]. Klinicheskaya i e′ksperimental'naya tireoidologiya, 7(2), 45–49. [in Russian].

Semenov, D. Yu., Saraisky, M. I., Koloskova, L. E., Boriskova, M. E., Saburova, I. Yu., Pankova, P. A., et al. (2011). Kombinirovannyj analiz vyyavleniya mutacii gena BRAF i e′kspressii galektina-3 v dooperacionnoj diagnostike raka shchitovidnoj zhelezy [Combined analysis of BRAF-gene mutation and galectin-3 expression in preoperative diagnostics of thyroid cancer]. Klinicheskaya i e′ksperimental'naya tireoidologiya, 7(2), 49–56. [in Russian].

Troshina, E., Masurina, N., Abesadse, I., Yushkov, P., & Garbusov, P. (2006). Rol' molekulyarnykh markerov v differencial'noj diagnostike follikulyarnykh opukholej shchitovidnoj zhelezy [Molecular Markers in Differential Diagnostics of Follicular Neoplasms of the Thyroid]. Klinicheskaya i e′ksperimental'naya tireoidologiya, 2(2), 22–26. [in Russian].

Khaziiev, V. V., & Hoidenko, N. I. (2013). Ekspresiia halektyna-3 u folikuliarnykh pukhlynakh shchytopodibnoi zalozy [Galectin-3 expression in follicular thyroid tumors]. Kharkivska khirurhichna shkola, 4, 124–127. [in Ukrainian].

Chernukhina, D. Yu., & Prilutsky, A. S. (2012). Rol' galektina-3, НВМЕ i citokeratina-19 v immunogistokhimicheskoj diagnostike papillyarnogo raka shchitovidnoi zhelezy [Role of Galectin-3, НВМЕ-1 and Cytokeratin 19 in Immunohistochemical Diagnosis of Papillary Thyroid Cancer]. Mezhdunarodnyj e′ndokrinologicheskij zhurnal, 5(45), 121–125. [in Ukrainian].

Bartolazzi, A., Orlandi, F., Saggiorato, E., Volante, M., Arecco, F., Rossetto, R., et al. (2008). Galectin-3-expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: a prospective multicentre study. The Lancet Oncology, 9(6), 543–549. doi: 10.1016/S1470-2045(08)70132-3.

Belfiore, A., & La Rosa, G. (2001). Fine-needle aspiration biosy of the thyroid. Endocrinology and Metabolism Clinics of North America, 30(2), 361–400.

Martins, L., Matsuo, S., Ebina, K., Kulcsar, M., Friguglietti, C., & Kimura, E. (2002). Galectin-3 messenger ribonucleic acid and protein are expressed in benign thyroid tumors. The Journal of Clinical Endocrinology & Metabolism, 87(10), 4806–4810. doi: 10.1210/jc.2002-020094.

Saggiorato, E., Aversa, S., Deandreis, D., Arecco, F., Mussa, A., Puligheddu, B., et al. (2004). Galectin-3: Presurgical marker of thyroid follicular epithelial cell-derived carcinomas. Journal of Endocrinological Investigation, 27(4), 311–317. doi: 10.1007/BF03351054.

Xu, X., Sola Gallego, J., Lotan, R., & El-Naggar, A. (1995). Differential expression of galectin-1 and galectin-3 in thyroid tumors. Potential diagnostic implications. Am. J. Patol., 147, 815–822.

Downloads

How to Cite

1.
Kebalo DI, Miroshnykova NP, Yurchenko KN, Pashchenko SM, Zvantseva OD, Fudashkina LM. Diagnostic usefulness of Galectin-3 in thyroid gland nodular lesions. Zaporozhye Medical Journal [Internet]. 2015Dec.29 [cited 2024Nov.23];17(6). Available from: http://zmj.zsmu.edu.ua/article/view/57017

Issue

No. 6 (2015): Zaporozhye medical journal

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)