Immunological status features in patients with tuberculosis/HIV co-infection

Authors

  • R. M. Yasinskiy Zaporizhzhia State Medical University,
  • A. G. Makarovich Zaporizhzhia Regional Clinical TB Dispensary of Zaporizhzhia Regional Council,
  • M. A. Arendaruk Zaporizhzhia Regional Clinical TB Dispensary of Zaporizhzhia Regional Council,
  • O. G. Makarova Zaporizhzhia Regional Clinical TB Dispensary of Zaporizhzhia Regional Council,

DOI:

https://doi.org/10.14739/2310-1210.2016.1.64163

Keywords:

Сoinfection Tuberculosis/HIV, CD4 -Lymphocyte Count

Abstract

 

Aim. Immunological status of the Tuberculosis/HIV co-infected patients determines course of the disease and treatment results.

Method and results. Immune status in 85 patients with newly diagnosed and recurrent pulmonary tuberculosis at co-infection was studied. CD4+- lymphocytes level in 1 mсL of blood was determined with flow cytofluorimetry method.

It was found that in the most part of patients (57.4%) with newly diagnosed tuberculosis HIV and TB were diagnosed at the same time and only 11.1% of patients received antiretroviral therapy before TB diagnostics. In 39.1 % of cases with newly diagnosed tuberculosis at HIV length of the period of HIV-positive status official registration was up to 1 year. CD4+-lymphocytes level was less than 200 cells/mcl in 62.9% of cases, and less than 50 cells/mcL - in 38.9%.

This indicated a low level of active HIV detection among population and late start of the treatment.

The number of patients with tuberculosis relapses at HIV in the deep immunosuppression stage was less (51.6%, only in 19.3% of whom CD4+-lymphocytes quantity was less than 50 cells/mcL) than that one at newly diagnosed tuberculosis at HIV. It can be explained by much greater percentage of HIV-positive status detection before tuberculosis relapse diagnosis (in 70.9% and 86.4% of patients suffered from HIV for more than 1 year) and more frequent and timely antiretroviral therapy appointment, that was assigned to 31.5% of patients.

Conclusion. Frequency of such clinical forms as infiltrative and disseminated TB statistically significantly increased in co-infected patients with a decrease of the number of CD4+-lymphocytes

References

Khaertynova, I. M., Valiev, R. Sh., Cibul'kin, A. P., Valiev, N. R., Khamzina, R. V., Lazarenko, O. G., & Romanenko, S. E′. (2009). Kliniko-immunologicheskie osobennosti VICH-infekcii, sochetannoj s tuberkulezom [Clinical and immunological features of HIV infection, combined with tuberculosis]. Tuberkulez i bolezni legkikh, 86(6), 41–46. [in Russian].

Khaertynova, I. M., Valiev, R. Sh., Romanenko, O. M., Khamzina, R. V., Valiev, N. R., Nasreeva, N. M., & Fajzutdinova, G. N. (2005). Kliniko-immunologicheskie osobennosti techeniya tuberkuleza v sochetanii s VICH-infekciej [Clinical and immunological features of the course of tuberculosis combined with HIV infection]. Problemy tuberkuleza i boleznej legkih, 10, 31–34. [in Russian].

Diedrich, C. R., & Flynn, J. L. (2011). HIV-1/Mycobacterium tuberculosis coinfection immunology: how does HIV-1 exacerbate tuberculosis? Infect. Immun., 79(4), 1407–1417. doi:10.1128/IAI.01126-10.

Musa, B. M., Musa, B., Muhammed, H., Ibrahim, N., & Musa, A. G. (2015). Incidence of tuberculosis and immunological profile of TB/HIV co-infected patients in Nigeria. Ann. Thorac. Med., 10, 185–192. doi: 10.4103/1817-1737.160838.

Liqidi, T., Gebre-Selassie, S., & Tseqaye, A. (2011). The immunological status of newly diagnosed tuberculosis patients co-infected with human immunodeficiency virus-1 in Adama Hospital, Ethiopia. Ethiop. Med. J., 49, 75–83.

Sullivana, Z. A., Wonga, E. B., Ndung'ua, T., Kasprowicza, V. O., & Bishaia, W. R. (2015). Latent and active tuberculosis infection increase immune activation in individuals co-infected with HIV. EBioMedicine, 2(4), 334–340. doi: http://dx.doi.org/10.1016/j.ebiom.2015.03.005.

Assefa, A., Gelaw, B., Getnet, G., & Yitayew, G. (2014). The effect of incident tuberculosis on immunological response of HIV patients on highly active anti-retroviral therapy at the university of Gondar hospital, northwest Ethiopia: a retrospective follow-up study. BMC Infectious diseases, 14, 468. doi: 10.1186/1471-2334-14-468.

Wondimeneh, Y., Muluye, D., & Belyhum, Y. (2012). Prevalence of pulmonary tuberculosis and immunological profile of HIV co-infected patients in northwest Ethiopia. BMC Res. Notes., 5, 331. doi: 10.1186/1756-0500-5-331.

Downloads

How to Cite

1.
Yasinskiy RM, Makarovich AG, Arendaruk MA, Makarova OG. Immunological status features in patients with tuberculosis/HIV co-infection. Zaporozhye medical journal [Internet]. 2016Mar.25 [cited 2024Apr.24];18(1). Available from: http://zmj.zsmu.edu.ua/article/view/64163

Issue

No. 1 (2016): Zaporozhye medical journal

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)