Recurrent spontaneous miscarriage: controversies in etiology and pathogenesis
DOI:
https://doi.org/10.14739/2310-1210.2016.1.64167Keywords:
Abortion Habitual, Genetic Polymorphism, Progesterone ReceptorsAbstract
Aim. We have studied and analyzed the available scientific sources over the past five years in order to systematize the available literature of recent years about research regarding recurrent spontaneous miscarriage.
Methods. During this studying we used methods of observation, systematization and content analysis.
Results. Modern views on etiology and pathogenesis of recurrent spontaneous miscarriage, in particular were presented in the article. Attention is focused on risk factors such as genetic disorders, anatomical abnormalities, endocrine pathology, infectious agents, autoimmune and immune disorders.
Conclusions. Our research iindicated role of progesterone and highlighted importance of genetic polymorphisms in the etiology and pathogenesis of recurrent spontaneous miscarriage.
References
(2012) Practice Committee Opinion of the American Society of Reproductive Medicine. Evaluation and treatment of recurrent pregnancy loss: a committee opinion. Fertil Steril, 98, 1103–11. doi: 10.1016/j.fertnstert.2012.06.048.
McNamee, K., Dawood, F., & Farquharson, R. (2012) Recurrent miscarriage and thrombophilia: an update. Curr Opin Obstet Gynecol, 24, 229–234. doi: 10.1097/GCO.0b013e32835585dc.
Royal College of Obstetricians and Gynaecologists. (2011). The Investigation and Treatment of Couples with Recurrent First-Trimester and Second-Trimester Miscarriages. Green-Top Guideline No. 17. London, RCOG Press.
Heuser, C., Dalton, J., Macpherson, C., Branch, D. W., Porter, T. F., & Silver, R. M. (2010) Idiopathic recurrent pregnancy loss recurs at similar gestational ages. Am J Obstet Gynecol, 203, 343.e1–5. doi: 10.1016/j.ajog.2010.05.010.
Hajder, M., Hajder, E., Dervisefendic, M., Samardzic, R., & Alic, E. (2013) Prolactinomas in infertile women: clinical and endocrine characteristics before and after 24 months of treatment with bromocriptine. Med Arh, 67, 181–4.
Brezina, P. R, & Kutteh, W. H. (2014) Classic and cuttingedge strategies for the management of early pregnancy loss. Obstet Gynecol Clin North Am, 41, 1–18. doi: 10.1016/j.ogc.2013.10.011.
Woelfer, B., Salim, R., Bannerjee, S., Elson, J., Regan, L., & Jurkovic, D. (2001) Reproductive outcomes in women with congenital uterine anomalies detected by three-dimensional ultrasound screening. Obstet Gynecol, 98, 1099–1103.
Sugiura-Ogasawara, M., Ozaki, Y., & Suzumori, N. (2013) Mullerian anomalies and recurrent miscar-riage. Curr Opin Obstet Gynecol, 25, 293–298. doi: 10.1097/GCO.0b013e3283632849.
Ernest, J. M., Marshburn, P. B., & Kutteh, W. H. (2011) Obstetric antiphospholipid syndrome: an update on pathophysiology and management. Semin Reprod Med, 29, 522–539. doi: 10.1055/s-0031-1293206.
Schist, D. J., & Hill, J. A. (2002) Recurrent Pregnancy Loss. Philadelphia, Lippincott Williams and Wilkins.
McNamee, K., Dawood, F., & Farquharson, R. G. (2012) Thrombophilia and early pregnancy loss. Best Pract Res Clin Obstet Gynaecol, 26, 91–102. doi: 10.1016/j.bpobgyn.2011.10.002.
Larsen, E. C., Christiansen, O. B., Kolte, A. M., & Macklon, N. (2013) New insights into mechanisms behind miscarriage. BMC Med, 11, 154. doi: 10.1186/1741-7015-11-154.
Lund, M, Nielsen, H. S., Hviid, T. V., Steffensen, R., Nyboe, A., & Christiansen, O. B. (2010) Hereditary thrombophilia and recurrent pregnancy loss: a retrospective cohort study of pregnancy outcome and complications. Hum Reprod, 25, 2978–2984. doi: 10.1093/humrep/deq280.
Kovalevsky, G., Gracia, C. R., Berlin, J. A., Sammel, M. D., & Barnhart, K. T. et al. (2004) Evaluation of the association between hereditary thrombophilias and recurrent pregnancy loss: a meta-analysis. Arch Intern Med, 164, 558–563. doi: 10.1001/archinte.164.5.558.
Greene, M. F., Hare, J. W., Cloherty, J. P., Benacerraf, B. R., & Soeldner, J. S. (1989) First-trimester hemoglobinA1 and risk for major malformation and spontaneous abortion in diabetic pregnancy. Teratology, 39, 225–31. doi: 10.1002/tera.1420390303.
Negro, R., Schwartz, A., Gismondi, R., Tinelli, A., Mangieri, T., & Stagnaro-Green, A. (2010) Increased pregnancy loss rate in thyroid antibody negative women with TSH levels between 2.5 and 5.0 in the first trimester of pregnancy. J Clin Endocrinol Metab, 95, E44–8. doi: 10.1210/jc.2010-0340.
Diejomaoh, M. F., Al-Azemi, M., Jirous, J., et al. (2006) Thyroid autoantibodies have no impact on pregnancy in women with recurrent miscarriage. ACOG abstract. Obstet Gynecol, 107, 98S.
Hirahara, F., Andoh, N., Sawai, K., Hirabuki, T., Uemura, T., & Minaguchi, H. (1998) Hyperprolactinemic recurrent miscarriage and results of randomized bromocriptine treatment trials. Fertil Steril, 70, 246–252. doi: http://dx.doi.org/10.1016/S0020-7292(98)90164-3.
Cocksedge, K. A., Saravellos, S. H., Metwally, M., et al. (2009) How common is polycystic ovary syndrome in recurrent miscarriage? Reprod Biomed Online, 19, 572–576.
Wang, Y., Zhao, H., Li, Y., Zhang, J., Tan, J., & Liu, Y. (2011) Relationship between recurrent miscarriage and insulin resistance. Gynecol Obstet Invest, 72, 245– 251. doi: 10.1159/000325165.
Carrington, B., Rai, R., & Regan, L. (2005) Polycistic ovaries, insulin resistance, hypofibrinolysis and recurrent miscarriage. J Soc Gynecol Investig, 12, 20.
Practice Committee of the American Society for Reproductive Medicine (2012). The clinical relevance of luteal phase deficiency: a committee opinion. Fertil Steril, 98, 1112–7. doi: 10.1016/j.fertnstert.2012.06.050.
Coutifaris, C., Myers, E. R., Guzick, D. S., Diamond, M. P., Carson, S. A., Legro, R. S. et al. (2004) Histological dating of timed endometrial biopsy tissue is not related to fertility status. Fertil Steril, 82, 1264–1272.
Su, M., Lin, S., & Chen, Y. (2011) Association of sex hormone receptor gene polymorphisms with recurrent pregnancy loss: a systematic review and meta-analysis. Fertil Steril., 96, 1435–1444. doi: 10.1016/j.fertnstert.2011.09.030.
Kryvopustov, O, & Dosenko, V. (2015) Single nucleotide polymorphisms in human progesterone receptor gene and its value in miscarriage or preterm delivery. Fiziol Zh., 61(2), 111–119.
Dosiou, C., & Giudice, L. C. (2005) Natural killer cells in pregnancy and recurrent pregnancy loss. Endocrine and immunologic perspectives. Endocr Rev, 26, 44–62.
Tang, A. W., Alfiveric, Z., & Quenby, S. (2011) Natural killer cells and pregnancy outcomes in women with recurrent miscarriage and infertility: a systemic review. Hum Reprod, 26, 1971–1980. doi: 10.1093/humrep/der164.
Nitrivalas, E. I., Kwam-Kim, J. Y. H., Gilman-Sachs, A., Chung-Bang, H., Ng, S. C., Beaman, K. D. et al (2001) Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown aetiology. Hum Reprod, 16, 855–861. doi: 10.1093/humrep/16.5.855.
Reagan, L, & Jivraj, S. (2001) Infection and pregnancy loss. Infection and Pregnancy, A.B. Maclean, L. Reagan, D. Carrington (eds), (p. 291–304). London, RCOG Press.
Lindbohm, M. L., Sallmen, M., & Taskinen, H. (2002) Effects of exposure to environmental tobacco smoke on reproductive health. Scand J Work Environ Health, 28(Suppl 2), 84–96.
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