Bone Metabolism Changes after Laparoscopic Greater Curvature Plication. A One-Year Study.

Authors

  • A. O. Nykonenko Zaporozhye State Medical University,
  • Ye. I. Gaidarzhi Zaporozhye State Medical University,
  • M. Bužga University of Ostrava,

DOI:

https://doi.org/10.14739/2310-1210.2016.2.69234

Keywords:

Bariatric surgery, Laparoscopic Plication, Bone Metabolism

Abstract

In addition to the positive effect of weight loosing after bariatric surgery, the post-operative period is often associated with significant changes in bone metabolism.
Aim. The aim of this study was to examine changes in bone turnover markers and indicators of dual-energy X-ray absorptiometry (DXA) within 12 months after laparoscopic greater curvature plication (LGCP).
Materials and methods. We studied 54 patients from class III obesity who underwent LGCP. The average preoperative weight of the patients was 125,519.1 kg, and BMI of 43.04.9 kg/m2. The gender distribution of the cohort was 35.2% man and 64.8% women. At three time points after the operation (at 3, 6 and 12 months) control examination was conducted that included DXA and markers of bone metabolism.
Results. After the surgical treatment we registered significant reduction of all the anthropometric indicators (0.05; EWL12 45.8±18.8%; EBL12 55.1±23.4%). According to the controlled studies on the 12th months, a significant increase in bone turnover markers was revealed (0.05; CTX, P1NP, OC, OPG, VTD) and reducing of PTH (0.05). The measure of DXA on the 12th month of observation showed no significant changes in bone metabolism. Strong positive correlation was uncovered between markers of bone metabolism: CTX / P1NP (r=0.790, p=0.000), CTX/OC, P1NP/OC (r=0.7, p=0.000), minor correlation between PTH/OC (r=0.249, p=0.027). We also report a minor and weak negative correlation between the markers of bone metabolism (CTX, P1NP, OC and VTD) and anthropometric data.
Conclusions. Twelve months post LGCP markers of bone turnover (CTX, P1NP, OC, OPG, VTD) were significantly increased. The increased level of VTD is associated with the loss of FAT. Also the change in DXA was detected.

References

World Health Organization. Overweight and Obesity. Retrieved from http://www.who.int/mediacentre/factsheets/fs311/en/.

Livingston, E. H. (2010) The incidence of bariatric surgery has plateaued in the U.S. Am. J. Surg., 200(3), 378–385. doi: 10.1016/j.amjsurg.2009.11.007.

Peterli, R., Borbély, Y., Kern, B., Gass, M., Peters, T., Thurnheer, M., et al. (2013) Early results of the Swiss Multicentre Bypass or Sleeve Study (SM-BOSS): a prospective randomized trial comparing laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass. Ann Surg., 258(5), 690–694. doi: 10.1097/SLA.0b013e3182a67426.

Sjöström, L. (2013) Review of the key results from the Swedish Obese Subjects (SOS) trial a prospective controlled intervention study of bariatric surgery. J Intern Med., 273(3), 219–234. doi: 10.1111/joim.12012.

Talebpour, M., & Amoli, B. S. (2007) Laparoscopic total gastric vertical plication in morbid obesity. J. Laparoendosc. Adv. Surg. Tech. A., 17(6), 793–798. doi: 10.1089/lap.2006.0128.

Yu, E. W. (2014) Bone metabolism after bariatric surgery. J. Bone Miner. Res., 29(7), 1507–1518. doi: 10.1002/jbmr.2226.

Elias, E., Casselbrant, A., Werling, M., Abegg, K., Vincent, R. P., Alaghband-Zadeh, J., et al. (2014) Bone mineral density and expression of vitamin D receptor-dependent calcium uptake mechanisms in the Proximal small intestine after bariatric surgery. Br. J. Surg., 101(12), 1566–1575. doi: 10.1002/bjs.9626.

Liu, C., Wu, D., Zhang, J. F., Xu, D., Xu, W. F., Chen, Y., et al. (2016) Changes in Bone Metabolism in Morbidly Obese Patients After Bariatric Surgery: A Meta-Analysis. Obes. Surg., 26(1), 91–97. doi: 10.1007/s11695-015-1724-5.

Stein, E. M., & Silverberg, S. J. (2014) Bone loss after bariatric surgery: causes, consequences, and management. Lancet Diabetes Endocrinol., 2(2), 165–174. doi: 10.1016/S2213-8587(13)70183-9.

Buchwald, H., Avidor, Y., Braunwald, E., Jensen, M. D., Pories, W., Fahrbach, K., & Schoelles, K. (2004) Bariatric surgery: a systematic review and meta-analysis. JAMA., 292(14), 1724–1737.

Schneider, B. E., & Mun, E. C. (2005) Surgical management of morbid obesity. Diabetes Care., 28(2), 475–480. doi: 10.2337/diacare.28.2.475.

Collazo-Clavell, M. L., Jimenez, A., Hodgson, S. F., & Sarr, M. G. (2004) Osteomalacia after Roux-en-Y gastric bypass. Endocr. Pract., 10(3), 195–198.

von Mach, M. A., Stoeckli, R., Bilz, S., Kraenzlin, M., Langer, I., & Keller, U. (2004) Changes in bone mineral content after surgical treatment of morbid obesity. Metabolism., 53(7), 918–921. doi: 10.1016/j.metabol.2004.01.015.

Slater, G. H., Ren, C. J., Siegel, N. et al. (2004) Serum fat-soluble vitamin deficiency and abnormal calcium metabolism after malabsorptive bariatric surgery. J. Gastrointest. Surg., 8(1), 48–55.

Costa, T. L., Paganotto, M., Radominski, R. B., Kulak, C. M., & Borba, V. C. (2015) Calcium metabolism, vitamin D and bone mineral density after bariatric surgery. Osteoporos Int., 26(2), 757–764. doi: 10.1007/s00198-014-2962-4.

World Health Organ Tech Rep Ser. (2000) Obesity: preventing and managing the global epidemic. Report of a WHO consultation., 894, i-xii, 1–253.

Fried, M., Hainer, V., Basdevant, A., Buchwald, H., Deitel, M., Finer, N., et al. (2008) Interdisciplinary European guidelines on surgery of severe obesity. Obes Facts., 1(1), 52–59. doi: 10.1159/000113937.

Deitel, M., & Greenstein, R. J. (2003) Recommendations for reporting weight loss. Obes Surg., 13(2), 159–160.

Vasikaran, S., Eastell, R., Bruyere, O., Foldes, A. J., Garnero, P., Griesmacher, A. et al. (2011) Markers of bone turnover for the prediction of fracture risk and monitoring of osteoporosis treatment: a need for international reference standards. Osteoporos Int., 22(2), 391–420. doi: 10.1007/s00198-010-1501-1.

(2012) Measurement of C-terminal telopeptide of type I collagen (CTX) in serum. Clin Biochem., 45(12), 928–935.

Hofbauer, L. C., & Heufelder, A. E. (2000) The role of receptor activator of nuclear factor-kB ligand and osteoprotegerin in the pathogenesis and treatment of metabolic bone diseases. J Clin Endocrinol Metab., 85, 2355–2363.

Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M. S., Luthy, R., et al. (1997) Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell, 89, 309–319. doi: 10.1016/S0092-8674(00)80209-3.

Li, J., Sarosi, I., Yan, X. Q., Morony, S., Capparelli, C., Tan, H. L., et al. (2000) RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci USA, 97, 1566–1571.

Delmas, P. D., Eastell, R., Garnero, P., Seibel, M. J., & Stepan, J. (2000) The use of biochemical markers of bone turnover in osteoporosis. Committee of Scientific Advisors of the International Osteoporosis Foundation. Osteoporos Int., 11(6), 2–17.

Cundy, T., Evans, M. C., Kay, R. G., Dowman, M., Wattie, D., & Reid, I.R. (1996) Effects of vertical-banded gastroplasty on bone and mineral metabolism in obese patients. Br J Surg., 83(10), 1468–1472. doi: 10.1002/bjs.1800831046.

Moreiro, J., Ruiz, O., Perez, G., Salinas, R., Urgeles, J. R., Riesco, M., & García-Sanz, M. (2007) Parathyroid hormone and bone marker levels in patients with morbid obesity before and after biliopancreatic diversion. Obes. Surg., 17(3), 348–354. doi: 10.1007/s11695-007-9063-9.

Ruiz-Tovar, J., Oller, I., Tomas, A., Llavero, C., Arroyo, A., Calero, A., et al. (2012) Mid-term effects of sleeve gastrectomy on calcium metabolism parameters, vitamin D and parathormone (PTH) in morbid obese women. Obes. Surg., 22(5), 797–801. doi: 10.1007/s11695-011-0582-z.

Martínez, P., Moreno, I., De Miguel, F., Vila, V., Esbrit, P., & Martínez, M. E. (2001) Changes in osteocalcin response to 1,25-dihydroxyvitamin D(3) stimulation and basal vitamin D receptor expression in human osteoblastic cells according to donor age and skeletal origin. Bone., 29(1), 35–41. doi: 10.1016/S8756-3282(01)00479-3.

Holick, M. F. (2007) Vitamin D deficiency. N. Engl. J. Med., 357, 266–281.

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1.
Nykonenko AO, Gaidarzhi YI, Bužga M. Bone Metabolism Changes after Laparoscopic Greater Curvature Plication. A One-Year Study. Zaporozhye Medical Journal [Internet]. 2016May23 [cited 2024Dec.25];18(2). Available from: http://zmj.zsmu.edu.ua/article/view/69234

Issue

No. 2 (2016): Zaporozhye medical journal

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Original research

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