Fatty acid composition of total lipids and phospholipids of muscular tissue and brain of rats under the impact of vibration

Authors

  • N. M. Kostyshyn Lviv National Medical University,
  • M. R. Grzegotsky Lviv National Medical University,
  • J. F. Rivis Institute of Agriculture in the Carpathian region NAAS of Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2016.3.77007

Keywords:

Fatty Acids, Phospholipids, Vibration, Muscle, Brain

Abstract

Fatty acids are important structural components of biological membranes, energy substrate of cells involved in fixing phospholipid bilayer proteins, and acting as regulators and modulators of enzymatic activity. Under the impact of vibration oscillations there can occur shifts in the ratio of different groups of fatty acids, and degrees of their saturation may change. The imbalance between saturated, monounsaturated and polyunsaturated fatty acids, which occurs later in the cell wall, disrupts fluidity and viscosity of lipid phase and causes abnormal cellular metabolism.

Aim. In order to study the impact of vibration on the level of fatty acids of total lipids in muscular tissue and fatty acid composition of phospholipids in muscles and brain, experimental animals have been exposed to vertical vibration oscillations with different frequency for 28 days.

Methods and results. Tissues fragments of hip quadriceps and brain of rats were used for obtaining methyl esters of fatty acids studied by the method of gas-liquid chromatography. It was found that the lipid content, ratio of its separate factions and fatty acid composition in muscular tissue and brain of animals with the action of vibration considerably varies. With the increase of vibration acceleration tendency to increase in absolute quantity of total lipids fatty acids can be observed at the account of increased level of saturated and monounsaturated ones. These processes are caused by activation of self-defense mechanisms of the body under the conditions of deviations from stabilized physiological norm, since adaptation requires certain structural and energy costs. Increase in the relative quantity of saturated and monounsaturated fatty acids in phospholipids of muscles and brain and simultaneous reduction in concentration of polyunsaturated fatty acids are observed.

Conclusion. These changes indicate worsening of structural and functional organization of muscles and brain cell membranes of rats due to increased viscosity of lipids and changes in their intramembrane dynamics.

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How to Cite

1.
Kostyshyn NM, Grzegotsky MR, Rivis JF. Fatty acid composition of total lipids and phospholipids of muscular tissue and brain of rats under the impact of vibration. Zaporozhye Medical Journal [Internet]. 2016Sep.6 [cited 2024Jun.22];18(3). Available from: http://zmj.zsmu.edu.ua/article/view/77007

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Section

Problems of pharmacy