Features of lipid metabolism in chronic heart failure of different genesis with concomitant overweight and obesity

Authors

  • Р.P. Bidzilya Zaporizhzhia State Medical University,

DOI:

https://doi.org/10.14739/2310-1210.2016.4.79779

Keywords:

Heart Failure, Etiology, Lipids Metabolism, Overweight, Obesity

Abstract

Recently clinical studies demonstrated reciprocal association between traditional cardiovascular risk factors, in particular, hyperlipidemia and obesity, with worse clinical outcomes in CHF. Unlike ischemic heart disease (IHD), where high levels of atherogenic and low of antiatherogenic lipids fraction traditionally associated with worsening of prognosis and course of disease, in conditions of the CHF proven negative impact of the reduction of lipid levels and body mass index. Demonstrated the phenomena called "cholesterol paradox" and "obesity paradox".

Aim. To study the features of lipid metabolism in CHF of different genesis with concomitant overweight and obesity.

Materials and methods. 240 patients with I–III functional class (FC) of the disease with concomitant overweight and abdominal obesity I–III degree were examined. FC of the disease was established according to the classification of New York Heart Association (NYHA).Normal, overweight and the degree of abdominal obesity was identified by calculating the body mass index. Etiologic factors of CHF were chronic forms of IHD, arterial hypertension, and/or a combination of both. With the help of biochemical blood tests lipid metabolism were assessed.

Results. The maximum values as atherogenic and antiatherogenic lipid indicators are investigated in non-ischemic (hypertensive) CHF. Patients with CHF of ischemic genesis are characterized by minimal values of atherogenic fractions of lipids. Patients with combined etiology of CHF occupy the intermediate position of atherogenic fractions content, while they demonstrate the minimum value in the antiatherogenic HDL-cholesterol.

Conclusion. Changes of lipid metabolism are varied depending on the etiology of CHF in patients with concomitant overweight and obesity and the most unfavorable in ischemic form of the disease. 

References

Ryndina N. G., Dunaeva, I. P., Mishina, M. M., & Pashtiani, R. V. (2013). Nutrityvnyi status ta functsionalnyi stan nyrok u khvorykh na KHSN ta diabetychnu nefropatiu z anemichnym syndromom [Nutritional status and renal function in patients with chronic heart failure and diabetic nephropathy with anemic syndrome]. Problema endokrynnoi patolohii, 2, 18–22. [in Ukrainian].

Rame, J. E. (2013). Is chronic heart failure is reversible metabolic syndrome? Heart Metab., 61, 8–14.

Rame, J. E. (2012). Chronic heart failure: a reversible metabolic syndrome? Circulation, 125 (23), 2809–2811. doi: 10.1161/CIRCULATIONAHA.112.108316.

Greene, S. J., Vaduganathan, M., Lupi, L., Ambrosy, A. P., Mentz, R. J., Konstam, M. A., et al. (2013). Prognostic Significance of Serum Total Cholesterol and Triglyceride Levels in Patients Hospitalized for Heart Failure With Reduced Ejection Fraction (from the EVEREST Trial). Am. J. Cardiol., 111, 574–581. doi: 10.1016/j.amjcard.2012.10.042.

Komukai, K., Minai, K., Arase, S., Ogawa, T., Nakane, T., Nagoshi, T., et al. (2012). Impact of body mass index on clinical outcome in patients hospitalized with congestive heart failure. Circulation, 76, 145–151.

Bonilla-Palomas, J. L., Gámez-López, A. L., Moreno-Conde, M., López-Ibáñez, C., Ramiro-Ortega, E., Castellano-García, P., & Villar-Ráez, A. (2016). Total cholesterol levels predict in-hospital mortality in patients with acute heart failure aged 70 years or older. Rev. Esp. Geriatr. Gerontol., 51(5), 280–3. doi: 10.1016/j.regg.2015.11.003.

https://www.ncbi.nlm.nih.gov/pubmed/26775170

Gastelurrutia, P., Pascual-Figal, D., Vazquez, R., Cygankiewicz, I., Shamagian, L. G., Puig, T., et al. (2011). Obesity paradox and risk of sudden death in heart failure results from the MUerte Subita en Insuficiencia cardiaca (MUSIC) study. Am. Heart J., 161, 158–164. doi: 10.1016/j.ahj.2010.10.018.

Shimizu, I., Yoshida, Y., Katsuno, T., Tateno, K., Okada, Sh., Moriya, J., et al. (2012). p53-induced adipose tissue inflammation is critically involved in the development of insulin resistance in heart failure. Cell Metab., 15, 51–64. doi: http://dx.doi.org/10.1016/j.cmet.2012.04.014.

Kanwar, G., & Kabra, R. (2016). A study of association between obesity and lipid profile. IJRANSS, 4(4), 69–74.

Voronkov, L. G., Amosova, K. M., Bahrii, A. E., Dziak, H. V., Diadyk, O. I., Zhariniv, O. Y., et al. (2013). Rekomendatsii z diahnostyky ta likuvannia khronichnoi sertsevoi nedostatnosti Asotsiatsii kardiolohiv Ukrainy ta Ukrainskoi asotsiatsii fakhivtsiv iz sertsevoi nedostatnosti [Guidelines for the diagnosis and treatment of chronic heart failure Association of cardiologists of Ukraine and the Ukrainian Association of specialists in heart failure]. Ukrainiskyi kardiolohichnyi zhurnal, 1 (Add), 6–44. [in Ukrainian].

How to Cite

1.
Bidzilya Р. Features of lipid metabolism in chronic heart failure of different genesis with concomitant overweight and obesity. Zaporozhye Medical Journal [Internet]. 2016Oct.13 [cited 2024Nov.2];18(4). Available from: http://zmj.zsmu.edu.ua/article/view/79779

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Section

Original research