Changes the state of secretory granules of the superficial epitheliocytes of the pyloric mucous membrane in the stomach of rats under the action of epichlorohydrin

Authors

  • A. S. Smirnov Lugansk State Medical University,
  • S. N. Smirnov Lugansk State Medical University,
  • M. A. Mirzebasov Lugansk State Medical University,

DOI:

https://doi.org/10.14739/2310-1210.2016.5.82693

Keywords:

Granules, Epithelial Cells, Epichlorohydrin, Adaptogen, Antioxidant

Abstract

The objective of the research was to examine the patterns of action of epichlorohydrin on the state of the secretory granules of the superficial epitheliocytes of the mucous membrane of pyloric part of stomach of rats.

Material and methods of the research. Mature male albino rats were used in the experiment. Rats of Group I were Control animals. Rats of Group II were administered epichlorohydrin. Rats of Group III were given Echinacea purpurea extract. Rats of Group IV were administered thiotriazoline. Rats of Group V were exposed to epichlorohydrin and extract of Echinacea purpurea, and rats of Group VI were exposed to epichlorohydrin and thiotriazoline.

Results of the research. The experiment showed that long-term inhalations of epichlorohydrin are accompanied by changes of secretory granules area, which remain after inhalations. The use of the extract of Echinacea purpurea on the background of epichlorohydrin prevents epichlorohydrin induced increase in the area of secretory granules on the thirtieth day of observation. Using thiotriazoline during inhalations of epichlorohydrin prevents the appearance of epichlorohydrin induced effects reducing the area of the secretory granules of the cytoplasm of epitheliocytes surface on the first day of observation and increasing their area on the thirtieth day of observation.

Conclusions. Inhalation of epichlorohydrin is accompanied by changes of the area of secretory granules in the cytoplasm of superficial epitheliocytes. Use of the extract of Echinacea purpurea and thiotriazoline on the background of epichlorohydrin prevents the epichlorohydrin induced changes in the area of the secretory granules of the cytoplasm of superficial epitheliocytes. 

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How to Cite

1.
Smirnov AS, Smirnov SN, Mirzebasov MA. Changes the state of secretory granules of the superficial epitheliocytes of the pyloric mucous membrane in the stomach of rats under the action of epichlorohydrin. Zaporozhye Medical Journal [Internet]. 2016Nov.10 [cited 2024Dec.22];18(5). Available from: http://zmj.zsmu.edu.ua/article/view/82693

Issue

No. 5 (2016): Zaporozhye medical journal

Section

Problems of pharmacy

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